Intracorporeally injectable composition for implanting highly concentrated cross-linked atelocollagen
US5314874A · kind A · utility
80Cited by
6References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 15, 1992 |
| Grant date | May 24, 1994 |
| Priority date | — |
| Expiry date | Apr 15, 2012 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61F2310/00365
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides an intracorporeally injectable non-toxic composition of atelocollagen having an excellent, long-lasting skin swelling effect due to its low viscosity, good fluidity, easy injectability and low antigenicity (without calcification) properties. The composition is prepared by treating an aqueous suspension of atelocollagen with a buffer for physiological conditions. The suspension can have atelocollagen content of 55 to 75 mg/ml, where approximately 20 to 100% by weight of atelocollagen is cross-linked with a polyepoxy compound.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.