Benzenesulphonamide derivatives
US5314891A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Sep 10, 1992 |
| Grant date | May 24, 1994 |
| Priority date | — |
| Expiry date | Sep 10, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention concerns benzenesulphonamide derivatives of the formula I ##STR1## wherein R.sup.1 is (1-4C)alkyl, (3-4C)alkenyl or (3-4C)alkynyl; PA1 R.sup.2 and R.sup.3 together form --A.sup.2 --X.sup.2 --A.sup.3 -- which defines a ring having 5 or 6 ring atoms, wherein A.sup.2 and A.sup.3 each is (1-3C)alkylene and X.sup.2 is oxy, thio, sulphinyl or sulphonyl; PA1 A.sup.1 is a direct link to X.sup.1 or is (1-3C)alkylene; PA1 X.sup.1 is oxy, thio or imino; PA1 Ar is optionally substituted phenylene; PA1 R.sup.4 is (1-4C)alkyl, fluoro-(2-4C)alkyl or optionally substituted phenyl or a heterocyclic moiety; PA1 R.sup.5 is hydrogen or (1-4C)alkyl; and PA1 R.sup.6 is hydrogen, halogeno, trifluoromethyl, (1-4C)alkyl or (1-4C)alkoxy; PA1 or a pharmaceutically-acceptable salt thereof; processes for their manufacture; pharmaceutical compositions containing them and their use as 5-lipoxygenase inhibitors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.