1,3-substituted cycloalkenes and cycloalkanes as central nervous system agents

US5314896A · kind A · utility

Assignee

• WARNER-LAMBERT COMPANY LLC · US

Inventors

• Bradley W. Caprathe · Redford, US
• Dennis M. Downing · Ann Arbor, US
• Juan C. Jaen · Plymouth, US
• Stephen J. Johnson · Ann Arbor, US
• William J. Smith, III · Ann Arbor, US
• Lawrence D. Wise · Ann Arbor, US
• Jonathan Wright · Ann Arbor, US
• David Juergen Wustrow · Ann Arbor, US

Key dates

• Filing date: Oct 15, 1992
• Grant date: May 24, 1994
• Expiry date: Oct 15, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

1,3-Substituted cycloalkenes and cycloalkanes are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.