Method of amphiphatic drug loading in liposomes by ammonium ion gradient

US5316771A · kind A · utility

Assignee

• YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. · IL

Inventors

• Yechezkel Barenholz · Jerusalem, IL
• Gilad Haran · Jerusalem, IL

Key dates

• Filing date: Dec 18, 1992
• Grant date: May 31, 1994
• Expiry date: Dec 18, 2012

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T428/2984
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An improved simple, efficient, safe, economical, and fast transmembrane ling procedure for efficient active loading of weak amphiphatic drugs into liposomes using the transmembrane gradient. The resulting liposomes loaded with the amphiphatic drug are stable and safe. A storagable form of loadable liposomes has extended period of stability. The reversed procedure is applicable for sustained release of liposome encapsulated drugs from ammonium liposomes.