Anti-HIV proteins GAP 31, DAP 30 and DAP 32 and therapeutic uses thereof

US5317009A · kind A · utility

Assignees

• NEW YORK UNIVERSITY · US
• American BioScience, Inc. · US
• National Institutes of Health, Office of Technology Transfer · US

Inventors

• Sylvia Lee-Huang · New York, US
• Hsiang-Fu Kung · Verona, US
• Paul Huang · Boston, US
• Philip L. Huang · Boston, US
• Peter Huang · New York, US
• Henry Huang · New York, US
• Hao-chia Chen · Potomac, US

Key dates

• Filing date: Aug 26, 1991
• Grant date: May 31, 1994
• Expiry date: Aug 26, 2011

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

New proteins, termed GAP 31, obtainable from the seeds of Gelonium multiflorum, and DAP 30 and DAP 32, obtainable from the leaves or seeds of Dianthus caryophyllus, or the above proteins produced by recombinant means, are useful for treating HIV infections. In treating HIV infections, the protein is administered alone or in conjunction with other anti-HIV therapeutics. Also provided are processes for purifying the proteins, DNA sequences encoding the proteins, hosts expressing the proteins, recombinant DNA methods for expressing the proteins, and antibodies specific for the proteins.