Heterocyclic hydrazide derivatives of monocyclic .beta.-lactam antibiotics
US5318963A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 30, 1990 |
| Grant date | Jun 7, 1994 |
| Priority date | — |
| Expiry date | Nov 30, 2010 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Antibacterial activity has been found in compounds of the formula. Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein: A is a bond or alkylene; PA1 Q completes a 5- or 6-membered saturated or unsaturated (including aromatic) heterocyclic ring having one or two, heteroatoms in the ring selected from nitrogen, ##STR2## sulfur or oxygen; X is attached to an available carbon atom in the heterocyclic ring and is hydrogen or oxo; PA1 Y is attached to an available carbon atom in the heterocyclic ring and is hydrogen, amino, hydroxyl, halogen, carboxamide, nitrile, or carboxyl, except that Y is not carboxyl when the bicyclic ring completed by Q is 2-quinolyl, 3-quinolyl, or quinoxalyl; PA1 and the remaining symbols are as defined in the specification.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.