Inhibition of the advanced glycosylation of proteins using substituted-1,2,4-triazoles
US5318982A · kind A · utility
6Cited by
0References
15Claims
0Family size
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Key dates
| Filing date | Dec 8, 1992 |
| Grant date | Jun 7, 1994 |
| Priority date | — |
| Expiry date | Dec 8, 2012 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/922
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises substituted 1,2,4-triazoles capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with the carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.