Process for the preparation of sugar epitopes
US5319077A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jun 12, 1992 |
| Grant date | Jun 7, 1994 |
| Priority date | — |
| Expiry date | Jun 12, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H17/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to a new process for the stereoselective preparation of Gal-.alpha.(1-3)/Gal-.beta.(1-4)/GlcNac trisaccharides of the formula ##STR1## and of .beta.(1-3)-linked oligolactosamines of the formula ##STR2## via partially alkylated glycals of the formula ##STR3## and other new intermediate products, wherein, depending on the formula, R is H, R'CH.sub.2 --, or allyl, PA1 R.sup.1 is H, R'CH.sub.2 --, allyl or R'CO--, PA1 R' is H, C.sub.1 to C.sub.3 -alkyl or (un)substituted phenyl, PA1 S is a spacer, preferably of the formula --(CH.sub.2).sub.n --COOR'', PA1 R'' is alkyl having 1 to 4 C atoms, PA1 X is N.sub.3 or --NHCOCH.sub.3, PA1 X is N.sub.3 or --NHCOCH.sub.3, PA1 Y is .beta.-OSiR.sub.2.sup.3 or .alpha.-OC(.dbd.NH)CCl.sub.3, PA1 R.sup.2 is C.sub.1 or C.sub.4 -alkyl or phenyl and PA1 m and n are integers from 1 to 4 or 4 to 12 respectively.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.