Quinoline derivative having serotonin-3 receptor antagonizing activity
US5319085A · kind A · utility
24Cited by
1References
4Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 16, 1993 |
| Grant date | Jun 7, 1994 |
| Priority date | — |
| Expiry date | Apr 16, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D451/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Quinoline derivatives represented by formula (I): ##STR1## wherein A-B-D represents --C(COO--Y).dbd.CH--C(OR).dbd. (wherein Y represents 8-methyl-8-azabicyclo[3.2.1]oct-3-yl group and R represents alkyl) or --C(OH).dbd.C(COX--Y)--CH.dbd. (wherein X represents --O-- or --NH--; and Y has the same meaning as described above), or a pharmaceutically acceptable salt thereof, possess potent 5HT.sub.3 antagonizing activity and are useful as antiemetic agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.