Patent · US Expired

Electrophoresis

US5320727A · kind A · utility

7Cited by
0References
11Claims
0Family size

Assignee

Inventor

Key dates

Filing dateJul 27, 1993
Grant dateJun 14, 1994
Priority date
Expiry dateJul 27, 2013

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07K1/28
  • WIPO fieldBiotechnology
  • WIPO sectorChemistry

Abstract

A method of separating or distinguishing proteins by isoelectric focusing (IEF), comprises fluorescently labelling proteins by reacting monobromobimane or monochlorobimane with free sylphydryl groups of proteins, and subjecting the labelled proteins to isoelectric focusing. The IEF may be followed by a second electrophoretic separation step, resulting in 2-D electrophoresis of flourescently pre-labelled proteins in a way that has not hitherto been possible.

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