Continuous release pharmaceutical compositions
US5320840A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 22, 1991 |
| Grant date | Jun 14, 1994 |
| Priority date | — |
| Expiry date | Jul 22, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Pharmaceutical compositions for continuous release of a physiologically active substance in which the physiologically active substance comprises a polypeptide covalently conjugated to a water soluble polymer show particularly desirable release characteristics. Polypeptides for use in the pharmaceutical compositions include G-CSF and solution stable derivatives thereof, human calcitonin and interleukin-2. The material of the composition may be a polylactide or biodegradable hydrogel derived from an amphipathic block copolymer. The compositions enable a therapeutically effective polypeptide to be continuously released over a prolonged period of time following a single administration of the pharmaceutical composition to a patient.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.