Patent · US Expired

Method and reagent for the determination of antithrombin III

US5320945A · kind A · utility

8Cited by

11References

8Claims

0Family size

Assignee

Boehringer Mannheim GmbH · DE

Inventors

Andreas Dessauer · Tutzing, DE
Reinhard Herz · Starnberg, DE
Helmut Lill · Wielenbach, DE

Key dates

Filing date	Sep 15, 1993
Grant date	Jun 14, 1994
Priority date	—
Expiry date	Sep 15, 2013

Classification

Technology area (CPC G)Physics
CPC primaryG01N2333/974
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

In order to determine antithrombin III in body fluids by reacting the sample with thrombin and a chromogenic substrate which forms a colour by the action of thrombin and measurement of the colour formed, the reaction is carried out in the presence of denaturing agents or of the tetrapeptide Gly-Pro-Arg-Pro and an oligopeptide is used as the substrate which has a sensitivity to thrombin which is a factor of 5 to 100-fold lower compared With Tos-Gly-Pro-Arg-pNA

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.