Detection of collagen degradation in vivo
US5320970A · kind A · utility
57Cited by
5References
12Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | May 31, 1991 |
| Grant date | Jun 14, 1994 |
| Priority date | — |
| Expiry date | May 31, 2011 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/811
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Methods of determining collagen degradation in vivo, by quantitating the concentration of a peptide in a body fluid, the peptide having the following structure: ##STR1## is hydroxylysyl pyridinoline or lysyl pyridinoline, and J is pyroglutamic acid or glutamine and (Leu) are optional leucines, are disclosed. Compositions useful in quantitating collagen peptides to determine the rate of bone resorption are prepared by treating bone with a protease, such as collagenase, and purifying the compositions so as to enrich them with peptides capable of binding to the monoclonal antibody MAb-1H11.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.