Phenothiazine derivatives, their preparation and pharmaceutical compositions containing them
US5321026A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 27, 1992 |
| Grant date | Jun 14, 1994 |
| Priority date | — |
| Expiry date | Jan 27, 2012 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/20
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
New phenothiazine derivatives of general formula (I) in which PA0 R represents 4- to 6-membered cycloalkyl, or represents --CH.sub.2 R" in which R" is hydrogen, alkyl containing 1 to 5 carbon atoms, alkenyl or alkynyl containing 2 to 4 carbon atoms, cycloalkyl (3- to 6-membered), phenyl, optionally substituted (with 1 or 2 halogen atoms or with a hydroxyl, alkyl, alkyloxy, trifluoromethyl or nitro radical) or heterocyclic selected from furyl, thienyl or pyridyl, and PA0 R' either represents a radical of general formula (IIa) in which R.sub.1 and R.sub.2, which may be identical or different, are alkyl, cycloalkylalkyl, hydroxyalkyl or acetyloxyalkyl or, together with the nitrogen atom to which they are attached, form a saturated or partially unsaturated 4- to 7-membered heterocycle optionally substituted with 1 or 2 alkyl, hydroxyalkyl or acetyloxyalkyl radicals, and PA0 R.sub.3 is phenethyl or alkyl optionally substituted with cycloalkyl (3 to 6 carbons) or benzoyl, or represents a radical of general formula (IIb) in which R.sub.1 and R.sub.2 are defined as above. The new products are useful as antispasmodics. ##STR1##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.