Substituted 2-thiazolyl tetrazolium salt indicators

US5322680A · kind A · utility

Assignee

• Miles Inc. · US

Inventors

• Gunther Beck · Leverkusen, DE
• Jürgen Köcher · Cologne, DE
• Klaus Wehling · Wuppertal, DE

Key dates

• Filing date: Apr 2, 1992
• Grant date: Jun 21, 1994
• Expiry date: Apr 2, 2012

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T436/184
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

2-Thiazolyl tetrazolium salt compounds characterized by a reflectance spectrum exhibiting an extended plateau above about 600-650 nm. Such compounds are useful as chromogenic indicators for reducing substances such as NADH. The reflectance plateau confers improved accuracy to analytical assays, particularly for the determination of analytes of medical diagnostic significance, in which a colorimetric response on a reagent carrier matrix is measured by reflectance.