Brain transcription factor, nucleic acids encoding same and uses thereof
US5324638A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 13, 1992 |
| Grant date | Jun 28, 1994 |
| Priority date | — |
| Expiry date | May 13, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/158
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention provides an isolated, purified transcription factor expressed in the telencephalic region of the brain of a developing animal or in structures derived therefrom. Also provided is a nucleic acid molecule, e.g., an RNA or a DNA molecule encoding the transcription factor of this invention. Further provided are a pharmaceutical composition comprising the transcription factor and a method of correcting an animal's defective synthesis of the transcription factor which comprises administering to the patient an effective amount of the pharmaceutical composition. Still further provided are an expression vector containing this nucleic acid molecule, a host vector system containing the vector and a method of producing the transcription factor comprising growing the host vector system under suitable conditions. This invention provides methods of diagnosing the overexpression of the transcription factor in tissue in which it is normally expressed and of detecting the presence of the factor in tissue.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.