Fibrin coated polymer surfaces
US5324647A · kind A · utility
47Cited by
8References
10Claims
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Key dates
| Filing date | Sep 14, 1993 |
| Grant date | Jun 28, 1994 |
| Priority date | — |
| Expiry date | Sep 14, 2013 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/10
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Surfaces of polymeric materials are coated with a layer of thermally denatured fibrinogen. The fibrinogen may be treated with thrombin to produce fibrin, and additional fibrinogen and factor XIII added to produce a cross-linked fibrin coating. The resulting coated surface is stable, anti-thrombotic and resistant to platelet adhesion. Polymeric materials coated in this way are useful in constructing vascular grafts and prosthetic devices, and provide test systems useful in the study of thrombogenesis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.