Human Y-interferon signal peptide-tumor necrosis factor(TNF) gene fusions
US5324655A · kind A · utility
28Cited by
3References
4Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 18, 1992 |
| Grant date | Jun 28, 1994 |
| Priority date | — |
| Expiry date | Feb 18, 2012 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/144
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A virion expression system for a desired protein packaged in an envelope derived from a retrovirus useful in administering proteins which cross cell membranes in order to serve their function. Preferred virions are those that carry an RNA sequence that encodes cytokines or lymphokines, and includes IL-2, multiple drug resistance protein, and TNF. Particularly disclosed is a DNA construct in which a gene encoding tumor necrosis factor (TNF) is directly linked to DNA encoding a human .gamma.-interferon signal peptide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.