Stereoselective microbial or enzymatic reduction of 3,5-dioxo esters to 3-hydroxy-5-oxo, 3-oxo-5-hydroxy, and 3,5-dihydroxy esters
US5324662A · kind A · utility
1Cited by
9References
8Claims
0Family size
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Key dates
| Filing date | May 15, 1992 |
| Grant date | Jun 28, 1994 |
| Priority date | — |
| Expiry date | May 15, 2012 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/938
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Microorganisms or reductases derived therefrom reduce a diketo ester ##STR1## to form the associated 3-hydroxy, 5-hydroxy, or 3,5-dihydroxy esters. Selected microorganisms produce the preferred stereoisomers ##STR2## which can be used to prepare antihypercholesterolemic agents such as ##STR3##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.