Patent · US Expired

Benzodiazepine analogs

US5324726A · kind A · utility

90Cited by

1References

4Claims

0Family size

Assignee

MERCK & CO., INC. · US

Inventors

Mark G. Bock · Hatfield, US
Ben E. Evans · Lansdale, US
Roger M. Freidinger · Hatfield, US

Key dates

Filing date	Oct 29, 1992
Grant date	Jun 28, 1994
Priority date	—
Expiry date	Oct 29, 2012

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Benzodiazepine analogs of the formula: ##STR1## wherein: R.sup.3 is ##STR2## --NH(CH.sub.2).sub.2 --.sub.3 NHCOR.sup.7, ##STR3## or --X.sup.11 NR.sup.18 SO.sub.2 (CH.sub.2).sub.q R.sup.7 ; R.sup.7 is O,S,HH, or NR.sup.15 with the proviso that X.sup.7 can be NR.sup.15 only when R.sup.1 is not H. are disclosed which are antagonists of gastrin and cholecystokinin (CCK) with enhanced aqueous solubility and have properties useful in the treatment of disorders of gastric secretion, appetite regulation, gastrointestinal motility, pancreatic secretion, and dopaminergic function, as well as in treatment producing potentiation of morphine and other opiate analgesics.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.