Method of inhibiting transformation of cells in which purine metabolic enzyme activity is elevated
US5324731A · kind A · utility
38Cited by
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17Claims
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Key dates
| Filing date | Nov 7, 1990 |
| Grant date | Jun 28, 1994 |
| Priority date | — |
| Expiry date | Nov 7, 2010 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/01
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of inhibiting growth, transformation and/or metastasis of mammalian cells, particularly epithelial cells, in which activity of at least one enzyme, which participates in purine metabolism or regulation of nucleotide levels or the relative ratios of their phosphorylated states, is elevated. In particular, a method of inhibiting transformation, growth and/or metastasis of mammalian cells in which a DNA tumor virus, a DNA tumor virus factor or other factor which has an equivalent effect on cells has acted.
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