Oxidization metabolites of 5-.alpha.-23-methyl-4-aza-21-nor-chol-1-ene-3, 20-dione
US5324734A · kind A · utility
6Cited by
17References
3Claims
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Key dates
| Filing date | Sep 15, 1992 |
| Grant date | Jun 28, 1994 |
| Priority date | — |
| Expiry date | Sep 15, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J73/005
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The compounds of formula (I) ##STR1## wherein R is selected from the group hydroxymethyl and carboxy, have been identified as metabolites of 5.alpha.-23-methyl-4-aza-21-nor-chol-1-ene-3,20-dione and are believed to be active as testosterone 5.alpha.-reductase inhibitors and would thus be useful for treatment of acne, seborrhea, female hirsutism or benign prostatic hypertrophy.
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