Compositions and methods for drug delivery and chromatography

US5324750A · kind A · utility

Assignee

• Australia Commercial Research & Development Limited · AU

Inventors

• Stephen Lincoln · Adelaide, AU
• John H. Coates · Toledo, US
• Christopher Easton · Adelaide, AU
• Stephen J. Van Eyk · Ludwigshafen, DE
• Bruce L. May · Hobart, AU
• Paramjit Singh · Calgary, CA
• Michael Williams · Melrose, US
• Martyn A. Stile · Jerramungup, AU

Key dates

• Filing date: Nov 20, 1992
• Grant date: Jun 28, 1994
• Expiry date: Nov 20, 2012

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N30/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Cyclodextrin derivatives and inclusion complexes having increased solubility and stability are provided. Cyclodextrin derivatives include amino and other modified cyclodextrins, and linked cyclodextrins. Inclusion complexes comprising the foregoing cyclodextrins, and processes for making the cyclodextrin derivatives are disclosed. Also disclosed are cyclodextrin derivatives comprising otherwise substituted or unsubstituted cyclodextrins covalently bonded to agents such as pharmaceuticals. The covalent bond, when broken, yields the agent in active form. Pharmaceutical compositions and methods of treating an animal host are also described, as well as chromatographic compositions and a method for separating racemic mixtures.