Proteins useful in the regulation of .kappa.B-containing genes

US5324818A · kind A · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Gary J. Nabel · Cambridge, US
• Roland Schmid · Ann Arbor, US
• Neil Perkins · Reading, GB

Key dates

• Filing date: Aug 21, 1991
• Grant date: Jun 28, 1994
• Expiry date: Aug 21, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/4702
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Proteins, and corresponding DNA and RNA sequences, useful for the regulation of expression of .kappa.B-containing genes are disclosed. These proteins are useful to either stimulate or inhibit the expression of .kappa.B-containing genes. Proteins stimulating the expression of .kappa.B-containing genes have an amino acid sequence at least 80% identical to the amino acid sequence of from position 1 to position 374 of p100 [SEQ ID NO: 2]. Proteins having an inhibitory effect on the expression of .kappa.B-containing genes have sequences either at least 80% identical to the amino acid sequence of from position 407 to the carboxyl end of p100 [SEQ ID NO: 2] or having an amino acid sequence at least 80% identical to the amino sequence of either from position 1 to 100 sor from position 101 to position 374 of p100 [SEQ ID NO: 2].