Phosphoramidite reagent for chemical synthesis of modified DNA
US5324831A · kind A · utility
14Cited by
6References
5Claims
0Family size
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Key dates
| Filing date | Apr 6, 1988 |
| Grant date | Jun 28, 1994 |
| Priority date | — |
| Expiry date | Apr 6, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H21/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
5,6-dihydro-5-azacytidine phosphoramidite is useful in the synthesis of oligonucleotides and DNA containing dihydro-5-aza- and 5-azacytosine bases. The modified oligonucleotides which contain 5-azacytosine residues at specific sites can be used to determine the mechanism of selective gene activation and the relationship existing between the presence of the triazine base and inhibition of DNA methylation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.