Patent · US Expired

Process for the preparation of (6S)- and (6R)-tetrahydrofolic acid

US5324836A · kind A · utility

8Cited by

7References

14Claims

0Family size

Assignee

EPROVA AG · CH

Inventors

Hans Muller · Kirkland, US
Martin Ulmann · Dachsen, CH
Josef Conti · Schaffhausen, CH
Gunter Murdel · Tengen, DE

Key dates

Filing date	Apr 8, 1993
Grant date	Jun 28, 1994
Priority date	—
Expiry date	Apr 8, 2013

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D475/04
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

For the preparation of (6S)- and (6R)-tetrahydrofolic acid and their addition salts with a sulfonic acid or with sulfuric acid, (6R,S)-tetrahydrofolic acid is reacted with a sulfonic acid or with sulfuric acid, the resulting acid addition salt is fractionally crystallized and, if desired, the (6S)- or (6R)-tetrahydrofolic acid is liberated from the resulting diastereomeric acid addition salts by treatment with a base and isolated.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.