Inhibition of the formation of nitrosamines
US5324857A · kind A · utility
2Cited by
10References
11Claims
0Family size
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Inventor
Key dates
| Filing date | Apr 28, 1992 |
| Grant date | Jun 28, 1994 |
| Priority date | — |
| Expiry date | Apr 28, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C291/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Reaction of amine-containing substrates with hydrogen peroxide can suffer from certain problems, especially in the presence of transition metals. These problems include both in situ generation of impurities and particularly nitrosamines, which are allegedly carcinogenic, and also impaired product formation. The problems can be ameliorated by employing in the reaction mixture free radical scavengers, including in particular phenols and polyhydroxy-substituted aromatic compounds. The scavengers are advantageously employed in conjunction with a metal chelating agent such as polycarboxylic acid or an organopolyphosphonic acid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.