Platelet derived growth factor agonists

US5326695A · kind A · utility

Assignee

• LUDWIG INSTITUTE FOR CANCER RESEARCH LTD · GB

Inventors

• Maria Andersson · Uppsala, SE
• Gudrun Backstrom · Uppsala, SE
• Ulla Engstrom · Uppsala, SE
• Carl-Henrik Heldin · Uppsala, SE
• Ulf Hellman · Uppsala, SE
• Arne stman · Uppsala, SE
• Bengt Westermark · Uppsala, SE

Key dates

• Filing date: May 15, 1992
• Grant date: Jul 5, 1994
• Expiry date: May 15, 2012

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention described PDGF modifiers. These are peptides which are derived from wild type PDGF monomers, and function as either agonists or antagonists. Various uses of these are described, as well as recombinant means of production. PDGF-B agonists comprising amino acids 97-180 of the PDGF-B monomer having the cysteines at amino acid residues 124 and 133 substituted, nucleic acid molecules encoding the agonists, plasmids, transformed host cells, and methods for causing receptor dimerization and autophosphorylation in a cell having PDGF-.beta. receptors on its surface comprising administering the PDGF-B agonist form part of the invention.