Aminobutanoic acid compounds having metalloprotease inhibiting properties

US5326760A · kind A · utility

Assignee

• Glaxo Group Limited · GB

Inventors

• Andrew B. McElroy · Morrisville, US
• Peter J. Brown · Cromwell, US
• David Harold Drewry · Durham, US
• James M. Salovich · Nashville, US
• Frank J. Schoenen · Lawrence, US

Key dates

• Filing date: Mar 15, 1993
• Grant date: Jul 5, 1994
• Expiry date: Mar 15, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F7/1804
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Aminobutanoic acids of the following formula (I): ##STR1## where R.sup.1 -R.sup.5 are a variety of substituents, novel intermediates, a pharmaceutical composition for treating inflammatory diseases, demyelinating diseases, and tumor metastasis, methods for such treatment and processes for preparing compounds of formula (I).