Piperidylmethyl-substituted chroman derivatives

US5326771A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Hans-Georg Heine · Krefeld, DE
• Bodo Junge · Wuppertal, DE
• Peter-Rudolf Seidel · Cologne, DE
• Rudolf Schohe-Loop · Wuppertal, DE
• Thomas Glaser · Overath, DE
• Jean De Vry · Stolberg, DE
• Wolfgang Dompert · Cologne, DE
• Henning Sommermeyer · Neunburg vorm Wald, DE

Key dates

• Filing date: Nov 30, 1992
• Grant date: Jul 5, 1994
• Expiry date: Nov 30, 2012

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Piperidylmethyl-substituted chroman derivatives can be prepared by first reducing corresponding chromancarboxylic acid derivatives, if appropriate with prior activation, with the cyclic amines and then reducing the carbonyl group, or by reacting chromanmethyl compounds directly with the cyclic amines. The substituted piperidylmethyl-substituted chroman derivatives can be employed as active compounds in medicaments, in particular for the treatment of diseases of the central-nervous system.