Cycloalkyl N-hydroxy derivatives having lipoxygenase inhibitory activity
US5326787A · kind A · utility
18Cited by
4References
5Claims
0Family size
Assignee
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Key dates
| Filing date | Aug 25, 1993 |
| Grant date | Jul 5, 1994 |
| Priority date | — |
| Expiry date | Aug 25, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C275/64
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of the structure ##STR1## where M is hydrogen, a pharmaceutically acceptable cation or metabolically cleavable group, R is alkyl, cycloalkyl, or NR.sup.1 R.sup.2, where R.sup.1 and R.sup.2 are hydrogen, alkyl, cycloalkyl alkonyl, or carbocyclic aryl, Y is alkylene, alkenylene, or cyclopropyl, and A is optionally substituted cycloalkyl or cycloalkylene are potent inhibitors of lipoxygenase enzymes and thus inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.