Chemiluminescent 3-(substituted Adamant-2'-Ylidene) 1,2-dioxetanes
US5326882A · kind A · utility
38Cited by
1References
3Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 30, 1992 |
| Grant date | Jul 5, 1994 |
| Priority date | — |
| Expiry date | Apr 30, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2603/74
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Enzymatically cleavable chemiluminescent 1,2-dioxetane compounds capable of producing light energy when decomposed, substantially stable at room temperature before a bond by which an enzymatically cleavable labile substituent thereof is intentionally cleaved, are disclosed. These compounds can be represented by the formula: ##STR1## The corresponding dioxetanes which, instead of being substituted at the 5' or 7', or at the 5' and 7' positions, instead contain a 4' methylene group, are also disclosed, as are intermediates for all these 3-substituted adamant-2'-ylidenedioxetanes, and their use as reporter molecules in assays.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.