Recombinant herpes simplex viruses vaccines and methods
US5328688A · kind A · utility
73Cited by
4References
45Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Sep 10, 1990 |
| Grant date | Jul 12, 1994 |
| Priority date | — |
| Expiry date | Sep 10, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2710/16643
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A virus is disclosed which is rendered avirulent by prevention of expression of an active product of a gene which is designated as .gamma..sub.1 34.5, which maps in the inverted repeats flanking the long unique sequence of herpes simplex virus DNA, and which is not essential for viral growth in cell culture. Viruses from which the gene was deleted or which carried stop codons are totally avirulent on intracerebral inoculation of mice.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.