Substituted (pyridinylamino)-indoles

US5328920A · kind A · utility

Assignee

• Hoechst Roussel Pharmaceuticals · US

Inventors

• Richard C. Effland · Bound Brook, US
• Joseph T. Klein · Bound Brook, US
• Lawrence L. Martin · Lebanon, US
• Gregory M. Shutske · Somerville, US
• Kevin J. Kapples · Little York, US
• John D. Tomer, IV · Perkasie, US

Key dates

• Filing date: Oct 21, 1992
• Grant date: Jul 12, 1994
• Expiry date: Oct 21, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

There are disclosed various compounds of the formula below, ##STR1## where R, R.sub.1, W, X, Y and Z are as defined in the specification; which are useful for alleviating various memory dysfunctions such as Alzheimer's disease, as modulators of neurotransmitter functions such as serotonergic and adrenergic, and as such are useful as antidepressants, anxiolytics, atypical antipsychotics, antiemetics, and for the treatment of personality disorders such as obsessive compulsive disorder.