N-alkylated 1,4-dihydropyridinedicarboxylic acid esters

US5328931A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Bruno Rosen · Wülfrath, DE
• Siegfried Zaiss · Wuppertal, DE
• Hartmund Wollweber · Wuppertal, DE
• Maarten de Jonge · Overath, DE
• Hans-Georg Dellweg · Wuppertal, DE

Key dates

• Filing date: Jul 21, 1992
• Grant date: Jul 12, 1994
• Expiry date: Jul 21, 2012

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/28
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

N-alkylated 1,4-dihydropyridinedicarboxylic acid esters can be prepared either by reaction of aldehydes with acetoacetic esters and amines, optionally with isolation of the corresponding ylidene compounds, or by reaction of aminocrotonic acid esters with ylidene compounds and subsequent alkylation of the NH function. The N-alkylated 1,4-dihydropyridinedicarboxylic acid esters can be employed as active compounds in medicaments, in particular as cerebral therapeutics.