Process for the preparation of tricyclo-[3.3.1.1.sup.3,7 ]dec-2-yl-[R-(R*,R*)]-3-(1H-indol-3-ylmethyl)-3-methyl-4,9-dioxo-7,11-di phenyl-10-oxa-2,5,8-triazaundecanate
US5329013A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 26, 1992 |
| Grant date | Jul 12, 1994 |
| Priority date | — |
| Expiry date | Oct 26, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C271/20
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides a process for the preparation of tricyclo- [3.3.1.1.sup.3,7 ]dec-2-yl-[R-(R*,R*)]-3-(1H-indol-3-ylmethyl)-3-methyl-4,9-dioxo-7,11-diph enyl-10-oxa-2,5,8-triazaundecanate, an important compound in the preparation of a new class of cholecystokinin inhibitors, wherein N-[(benzyloxy)carbonyl]-(R)-.beta.-amino-1-azido-2-phenylethane is hydrogenated, and subsequently, by means of carbon dioxide, the resulting N.sup..beta. -[(benzyloxy)-carbonyl]-(R)-.beta.-amino-2-phenylethylamine carbonate is precipitated out. This is coupled by the carbodiimide process with N-[(2-adamantyloxy)-carbonyl]-.alpha.-methyl-R-tryptophane.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.