Methods of preparing bulk delivery matrices by solid-state dissolution

US5330764A · kind A · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Dilip J. Gole · Ann Arbor, US
• R. Saul Levinson · Harrisburg, US
• James Carbone · Grafton, US
• J. Desmond Davies · Grosse Pointe Farms, US

Key dates

• Filing date: Jul 23, 1991
• Grant date: Jul 19, 1994
• Expiry date: Jul 23, 2011

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2800/56
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method is disclosed for preparing pharmaceutical and other matrix systems that comprises solidifying a matrix composition dissolved or dispersed in a first solvent and subsequently contacting the solidified matrix with a second solvent that is substantially miscible with the first solvent at a temperature lower than the solidification point of the first solvent, the matrix components being substantially insoluble in the second solvent, whereby the first solvent is substantially removed resulting in a usable matrix.