MCC gene (mutated in colorectal cancer) used for diagnosis of cancer in humans

US5330892A · kind A · utility

Assignees

• THE JOHNS HOPKINS UNIVERSITY · US
• University of Utah · US
• The Cancer Institute · JP

Inventors

• Bert Vogelstein · Baltimore, US
• Kenneth W. Kinzler · Baltimore, US
• Raymond L. White · Salt Lake City, US
• Yusuke Nakamura · Bunkyo, JP

Key dates

• Filing date: Mar 13, 1991
• Grant date: Jul 19, 1994
• Expiry date: Mar 13, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/118
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A new human gene termed MCC is disclosed. Methods and kits are provided for assessing mutations of the MCC gene in human tissues and body samples. Gross rearrangement and point mutations in MCC are observed in human tumor cells. MCC is expressed in most normal tissues. These results suggest that MCC is a tumor suppressor.