Growth hormone fusion proteins, methods of production, and methods of treatment
US5330971A · kind A · utility
38Cited by
3References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 22, 1991 |
| Grant date | Jul 19, 1994 |
| Priority date | — |
| Expiry date | Jan 22, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A plasmid encoding a fusion protein comprising a first polypeptide having growth hormone activity and a second polypeptide which may be one of insulin growth factor (IGF)-I or IGF-II and their analogues, chicken histone H2A.I or human transcription factor SPI-lac Z with an optional cleavage sequence between the first and second polypeptides. The fusion protein may be used: 1) to treat growth hormone deficiencies; 2) to suppress loss of body protein following trauma such as burns or infection; 3) for farm animals to increase growth rates and efficiency of food conversion; 4) and to support growth of cells in culture.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.