Heterocycles substituted with biphenyl-3-cyclobutene-1,2-dione derivatives
US5330989A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 11, 1992 |
| Grant date | Jul 19, 1994 |
| Priority date | — |
| Expiry date | Sep 11, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D239/94
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Biphenyl derivatives of cyclobutene-1,2-dione of formula 1 are angiotensin II antagonists and are useful for the treatment of hypertension and congestive heart failure ##STR1## wherein: Y is O, NR.sup.7, NCOR.sup.7 ; or R.sup.5 and Y taken together represent a linking chain of N.dbd.CR.sup.8 N; or R.sup.5 and Y taken together represent a linking chain of (CR.sup.9 R.sup.10).sub.n CON where n=1,2,3,4, or 5; PA0 X is N, CR.sup.7 ; PA0 Z is N, CR.sup.7 ; PA0 R.sup.1 is H, alkyl, benzyl, alkoxyalkyl, phenyl; PA0 R.sup.2 is H, alkyl, benzyl, alkoxyalkyl, phenyl, alkoxy, alkyl-OH, perfluoroalkyl, F, Cl, Br, I, NR.sup.7 R.sup.8 ; PA0 R.sup.3 is H, alkyl, benzyl, alkoxyalkyl, phenyl, alkoxy, alkyl-OH, perfluoroalkyl, F, Cl, Br, I, NR.sup.7 R.sup.8 ; PA0 R.sup.4 is H, NR.sup.7 R.sup.8, OR.sup.1, CN, F, Cl, I, Br, perfluoroalkyl, alkyl, phenyl, alkoxy, alkyl-OH, alkoxyalkyl, --(CH.sub.2).sub.n CO.sub.2 R.sup.1, --(CH.sub.2).sub.n CONR.sup.7 R.sup.8 where n=1, 2, 3, 4, or 5; PA0 R.sup.5, R.sup.6 is independently chosen from H, alkyl, benzyl, alkoxyalkyl, phenyl, F, Cl, NR.sup.7 R.sup.8 ; or R.sup.5 and R.sup.6 taken together represent a linking chain of CR.sup.9 R.sup.10 of up to 6 linking me…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.