Thioester enantiomeric compounds and their therapeutic uses
US5331008A · kind A · utility
9Cited by
1References
5Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 1, 1993 |
| Grant date | Jul 19, 1994 |
| Priority date | — |
| Expiry date | Feb 1, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/07
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The (R) or (S) isomer of acetorphan or N-/(acetylthiomethyl)-2-oxo-1-phenyl-3-propyl/(S) alanine methyl ester is prepared by splitting of racemic acetylthio-3-benzyl-2-propanoic acid by reaction with ephedrin, separation of the enantiomeric salt obtained, then freeing of the acid and coupling with the corresponding amino acid ester. The obtained preparations possess remarkable therapeutic activities and can notably be used as drugs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.