Oxazinone derivative
US5332734A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 10, 1992 |
| Grant date | Jul 26, 1994 |
| Priority date | — |
| Expiry date | Dec 10, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed is a novel oxazinone derivative represented by formula (I) given below or a pharmaceutically acceptable acid-addition salt thereof, which is useful as an anti-inflammatory agent, an agent for suppressing neutrophil infiltration and as a serine protease inhibitor: ##STR1## where A includes, for example, ##STR2## in which W is --O--, --S--, --CH.dbd.CH-- or --NR.sup.9 -- or means that (CH.sub.2).sub.n is directly bonded to (CH.sub.2).sub.n, PA1 V.sup.2 is .dbd.CR.sup.12 -- or .dbd.N--, and PA1 D is 5 to 7-membered carbon ring or hetero ring; PA1 X is --O--, --S--, --CO--, or --NR.sup.15 or means that A is directly bonded to (CH.sub.2).sub.l ; PA1 Y is --O--, --CH.dbd.CH-- or --NR.sup.16 -- or means that (CH.sub.2).sub.l is directly bonded to Z; PA1 Z is --CH.sub.2 -- or --CO--; and PA1 l is an integer of 0 to 4. PA1 Further, R and R.sup.1 to R.sup.16 are hydrogen atom, lower alkyl group, etc.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.