Oxime derivatives
US5332757A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Feb 8, 1993 |
| Grant date | Jul 26, 1994 |
| Priority date | — |
| Expiry date | Feb 8, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention concerns oxime derivatives of the formula I ##STR1## wherein R.sup.4 includes hydrogen, carboxy, carbamoyl, amino, cyano, trifluoromethyl, (1-4C)alkylamino, di-(1-4C)alkylamino and (1-4C)alkyl; PA1 R.sup.5 includes hydrogen, (1-4C)alkyl, (3-4C)alkenyl, (3-4C)alkynyl, (2-5C)alkanoyl, halogeno-(2-4C)alkyl and hydroxy-(2-4C)alkyl; PA1 Ar.sup.1 is phenylene or a heteroaryl diradical; PA1 A.sup.1 is a direct link to X.sup.1, or A.sup.1 is (1-4C)alkylene; PA1 X.sup.1 is oxy, thio, sulphinyl or sulphonyl; PA1 Ar.sup.2 is phenylene or a heteroaryl diradical; PA1 R.sup.1 is (1-4C)alkyl, (3-4C)alkenyl or (3-4C)alkynyl; and PA1 R.sup.2 and R.sup.3 together form a group of the formula -A.sup.2 -X.sup.2 -A.sup.3 - which together with the carbon atom to which A.sup.2 and A.sup.3 are attached define a ring having 5 or 6 ring atoms, wherein each of A.sup.2 and A.sup.3 is (1-3C)alkylene and X.sup.2 is oxy, thio, sulphinyl, sulphonyl or imino; PA1 or a pharmaceutically-acceptable salt thereof; processes for their manufacture; pharmaceutical compositions containing them and their use as 5-lipoxygenase inhibitors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.