Method for preparing a benzaldehyde intermediate
US5332840A · kind A · utility
1Cited by
1References
3Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 27, 1993 |
| Grant date | Jul 26, 1994 |
| Priority date | — |
| Expiry date | May 27, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D493/18
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method is provided for preparing a chiral benzaldehyde of the structure ##STR1## by acylating an anhydride of the structure ##STR2## with a chiral oxazolidine of the structure ##STR3## where Q is MgHal or Li, and X, Y and Z are as described herein, to form a keto acid which is reduced and cyclized. The resulting benzaldehyde may be used in making the final anti-thrombotic - anti-vasospastic compounds. Novel intermediates are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.