Compositions which are immunologically crossreactive with antibodies and preparative methods therefor

US5334702A · kind A · utility

Assignees

• The Board of Trustees of the University of Illinois · US
• The Trustees of the University of Pennsylvania · US

Inventors

• Mark I. Greene · Levittown, US
• Horacio Uri Saragovi · Montréal, CA
• Michael Kahn · Los Angeles, US

Key dates

• Filing date: Aug 20, 1992
• Grant date: Aug 2, 1994
• Expiry date: Aug 20, 2012

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compositions which are immunologically crossreactive with antibodies are provided, together with preparative and therapeutic methods therefor. The compositions preferably comprise a plurality of covalently bound synthetic compounds, at least one of which is individually crossreactive with at least one complementarity determining region (CDR) of the antibody. Preferred processes for preparing the immunologically crossreactive compounds comprise identifying chemical functionality such as hydroxyl groups in the CDR which participates in at least one immunological binding phenomena, determining the three-dimensional positioning of the chemical functionality, and synthesizing a compound which comprises substantially the same chemical functionality as the CDR and which has at least one conformation wherein the three-dimensional positioning of the chemical functionality is substantially identical to the three-dimensional positioning of the chemical functionality of the CDR.