Oxidation of cephalomannine with ozone in the presence of taxol
US5334732A · kind A · utility
8Cited by
0References
5Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 10, 1993 |
| Grant date | Aug 2, 1994 |
| Priority date | — |
| Expiry date | Sep 10, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D305/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for oxidizing cephalomannine and related taxanes in the presence of taxol is described. The process involves the use of ozone which is able to oxidize cephalomannine and easily oxidizable taxanes while leaving taxol essentially unchanged. Taxol can then be separated from the oxidized cephalomannine and other oxidized taxanes using conventional procedures. A process for oxidizing taxanes is also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.