Method of preparing substituted malonic ester anilides and malonic acid mono-anilides
US5334747A · kind A · utility
59Cited by
2References
8Claims
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Key dates
| Filing date | Apr 7, 1992 |
| Grant date | Aug 2, 1994 |
| Priority date | — |
| Expiry date | Apr 7, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Malonic mono-ester mono-anilides and malonic acid mono-anilides and bis-anilides are produced by reaction of malonic acid di-alkyl esters with an aniline in the presence of a stoichiometric amount, based on the aniline, of an alkali alcoholate, accompanied by the initial formation of alkali salts of mono-ester mono-anilides or malonic-acid bis-anilides. Neutralization results in the formation of free malonic mono-ester mono-anilide or malonic-acid bis-anilide and saponification forms the malonic acid mono-anilide. Chloro-substituted anilides of cyclopropyl-1,1-dicarboxylic acid and their mono-esters are preferred.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.