Process for the preparation of cinnamic acid derivatives

US5334750A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Dieter Kaufmann · Heidenheim, DE
• Carsten Hesse · Krefeld, DE
• Thomas Himmler · Odenthal, DE

Key dates

• Filing date: Mar 31, 1993
• Grant date: Aug 2, 1994
• Expiry date: Mar 31, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C67/343
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Cinnamic acid derivatives, in particular 2-ethylhexyl p-methoxycinnamate and 2-isoamyl p-methoxycinnamate, are prepared avoiding particular effort for workplace hygiene and ecology by using bromoaromatic and acrylic acid derivatives in the presence of palladium catalysts and a large excess of phosphane (based on the palladium), in the presence of an inorganic base and in the presence of alcohols and/or a phase transfer catalyst.