Glass container internally coated with a silicone and having an in situ freeze-dried solid product therein, and process of making the same

US5335769A · kind A · utility

Assignee

• Schwartz Pharma AG · DE

Inventors

• Karin Klokkers-Bethke · Monheim, DE
• Wilfried Fischer · Holzkirchen, DE

Key dates

• Filing date: Nov 5, 1992
• Grant date: Aug 9, 1994
• Expiry date: Nov 5, 2012

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T428/31612
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A freeze-drying process which reduces loss of the freeze-dried product comprising adding a liquid solution comprising a solid product dissolved in a solvent to a glass container having its inside surface coated with a silicone material; subjecting the container with the liquid solution therein to acceptable operable freeze-drying conditions to remove the solvent and leave the solid product in the container in the form of a dense compact coherent solid; and sealing the container to maintain the solid product stable over a useful storage shelf life. An article of manufacture comprising a sealed glass container having its inside surface coated with a silicone material and containing an in situ freeze-dried dense compact coherent solid product.