Use of charged phospholipids to reduce nanoparticle aggregation

US5336507A · kind A · utility

Assignee

• Sterling Winthrop Inc. · US

Inventors

• George C. Na · Fort Washington, US
• Natarajan Rajagopalan · Kothagudem, IN

Key dates

• Filing date: Dec 11, 1992
• Grant date: Aug 9, 1994
• Expiry date: Dec 11, 2012

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S977/847
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention discloses a composition comprised of nanoparticles having a non-ionic surfactant as a surface modifier adsorbed on the surface thereof and a charged phospholipid as a cloud point modifier associated therewith, which cloud point modifier is present in an amount sufficient to increase the cloud point of the surface modifier. A preferred non-ionic surfactant surface modifier is a poloxamine or tyloxapol, and preferred charged phospholipid cloud point modifiers include dimyristoyl phosphatidyl glycerol. This invention further discloses a method of making nanoparticles having a non-ionic surfactant as a surface modifier adsorbed on the surface and a charged phospholipid as a cloud point modifier associated therewith, comprised of contacting said nanoparticles with the cloud point modifier for a time and under conditions sufficient to increase the cloud point of the surface modifier.